Human Growth Factors & Cytokines
Recombinant Human TNF-β (Insect-derived)





 





		Synonyms :
Tumor Necrosis Factor-beta, TNFSF1, Lymphotoxin-alpha (LT-alpha)



		Description :
TNF-β is a potent mediator of inflammatory and immune responses.  It belongs to the TNF superfamily of ligands and signals through TNFR1 and TNFR2.  TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-α.  Like TNF-α, TNF-β is involved in the regulation of various biological processes incuding cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission.  TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface.  TNF-β is cytotoxic to a wide range of tumor cells.  Recombinant human TNF-β is a secreted 172 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.  Due to glycosylation, TNF-β has an approximate MW of 19.3 kDa based on SDS-PAGE gel amd Mass Spectrometry.* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.



		Catalog #:
300-01BH



		Source :
 (BTI-Tn-5B1-4) High-5  Insect Cells*



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
The ED50 was determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.



                AA Sequence :
GVGLTPSAAQ TARQHPKMHL AHSTLKPAAH LIGDPSKQNS LLWRANTDRA FLQDGFSLSN NSLLVPTSGI YFVYSQVVFS GKAYSPKATS SPLYLAHEVQ LFSSQYPFHV PLLSSQKMVY PGLQEPWLHS MYHGAAFQLT QGDQLSTHTD GIPHLVLSPS TVFFGAFAL 



		PubMed Link :
TNFbeta+AND+human


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
20μg
$195 
 


 



        Size C
1mg
$3000 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.